Nowadays, Otilonium bromide is a topic on everyone's lips. From its impact on society to its various implications, Otilonium bromide has captured the attention of a wide spectrum of people around the world. Whether we are talking about its influence in politics, economics, technology or any other field, Otilonium bromide has proven to be a topic worthy of analysis and debate. In this article, we will explore some of the most relevant facets of Otilonium bromide and what its presence means for the future. Without a doubt, Otilonium bromide is a topic that will continue to generate interest and discussion in the coming years, and it is crucial to understand its importance in the current landscape.
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Clinical data | |
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Trade names | Spasmoctyl 40, Doralin |
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ECHA InfoCard | 100.043.128 |
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Formula | C29H43BrN2O4 |
Molar mass | 563.577 g·mol−1 |
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Otilonium bromide, sold under the trade name Spasmomen among others, is an antimuscarinic and calcium channel blocker used to relieve spasmodic pain of the gut, especially in irritable bowel syndrome. This means it works in the gut themselves, by relaxing the small muscles of the intestines, which results in relieving cramps and therefore reduces pain.
A pooled analysis of three clinical trials suggest that otilonium is more effective than placebo for the treatment of irritable bowel syndrome.
Otilinium binds to both muscarinic receptors and tachykinin NK2 receptors. It has been shown to inhibit L-type and T-type calcium channels, actions which may contribute to or determine its effects in the gut.
When taken orally, very little of the drug is absorbed into the rest of the body, which means that most of its actions remain confined to the gastrointestinal system.