AC-42

In today's world, AC-42 has gained unprecedented relevance, gaining more and more attention and generating all kinds of opinions, debates and research. Since AC-42 arrived on the scene, it has deeply impacted various areas of society, influencing everything from popular culture to politics and technology. In this article, we will explore in detail the impact of AC-42 on different aspects of everyday life, analyzing its consequences and possible implications for the future. Without a doubt, AC-42 has been and will continue to be a topic of great interest and importance for our contemporary society.

AC-42
Names
Preferred IUPAC name
4-n-butyl-1-(4-(2-methylphenyl)-4-oxo-1-butyl)-piperidine
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
  • InChI=1S/C20H31NO/c1-3-4-9-18-12-15-21(16-13-18)14-7-11-20(22)19-10-6-5-8-17(19)2/h5-6,8,10,18H,3-4,7,9,11-16H2,1-2H3
    Key: ANTKBACNWQHQJE-UHFFFAOYSA-N
  • O=C(C=1C=CC=CC1C)CCCN2CCC(CC2)CCCC
Properties
C20H31NO
Molar mass 301.474 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).

AC-42 is a selective, allosteric agonist of the M1 muscarinic acetylcholine receptor. AC-42 was the first selective M1 agonist to be discovered and its derivatives have been used to study the binding domain of the M1 receptor.

References

  1. ^ Decker, Michael; Holzgrabe, Ulrike (2012). "M1 muscarinic cetylcholine receptor allosteric modulators as potential therapeutic opportunities for treating Alzheimer's disease". MedChemComm. 3 (7): 752. doi:10.1039/c2md20025b.
  2. ^ Sams, Anette G.; Hentzer, Morten; Mikkelsen, Gitte K.; Larsen, Krestian; Bundgaard, Christoffer; Plath, Niels; Christoffersen, Claus T.; Bang-Andersen, Benny (9 September 2010). "Discovery of N -{1-oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): An Allosteric Muscarinic M 1 Receptor Agonist with Unprecedented Selectivity and Procognitive Potential". Journal of Medicinal Chemistry. 53 (17): 6386–6397. doi:10.1021/jm100697g. PMID 20684563.
  3. ^ Daval, Sandrine B.; Valant, Céline; Bonnet, Dominique; Kellenberger, Esther; Hibert, Marcel; Galzi, Jean-Luc; Ilien, Brigitte (8 March 2012). "Fluorescent Derivatives of AC-42 To Probe Bitopic Orthosteric/Allosteric Binding Mechanisms on Muscarinic M1 Receptors" (PDF). Journal of Medicinal Chemistry. 55 (5): 2125–2143. doi:10.1021/jm201348t. PMID 22329602.


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