In this article, we will further explore Muscarinic toxin 7 and its impact on today's society. Muscarinic toxin 7 has been a topic of interest and discussion for many years, and its relevance remains palpable today. From its origins to its evolution over time, Muscarinic toxin 7 has left a significant mark on various aspects of human life, affecting everything from interpersonal relationships to political and economic dynamics. Through this detailed analysis, we will seek to better understand Muscarinic toxin 7's role in today's world and reflect on its influence in the future.
Muscarinic toxin 7 (MT7) is one member of a family of small peptides of 65 amino acidresidues
derived from the venom of African mamba snakes (Dendroaspis angusticeps), which mainly target M1-subtype of muscarinic receptor. Muscarinic toxins like the nicotinic toxins have the three-finger fold structure, characteristic of the large superfamily of toxins that act at cholinergic synapses.
Muscarinic toxin 7
Crystal structure of Muscarinic toxin 7 (MT7) from PDB 2VLW
MT7 is likely to bind to the human M1 receptor in its dimer form with the tips of MT7 loops II and III contacting one hM1 protomer and the tip of loop I binds to the other protomer.
References
^Fruchart-Gaillard C, Mourier G, Marquer C, Stura E, Birdsall NJ, Servent D (December 2008). "Different interactions between MT7 toxin and the human muscarinic M1 receptor in its free and N-methylscopolamine-occupied states". Mol. Pharmacol. 74 (6): 1554–63. doi:10.1124/mol.108.050773. PMID18784346. S2CID9480977.
