Niguldipine

In today's world, Niguldipine is a relevant issue that impacts a large number of people in different aspects of their lives. Whether on an individual, societal or global level, Niguldipine has gained significant importance and has generated a wide range of opinions and debates. In this article, we will delve into the world of Niguldipine to analyze its origin, evolution and consequences. We will discover how Niguldipine has marked a before and after in today's society and we will explore possible solutions and alternatives to address this issue effectively. Join us on this journey to better understand the importance of Niguldipine in our world today.

Niguldipine
Names
IUPAC name
3-3-(4,4-Diphenyl-1-piperidyl)propyl 5-methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
UNII
  • InChI=1S/C36H39N3O6/c1-25-31(34(40)44-3)33(27-12-10-17-30(24-27)39(42)43)32(26(2)37-25)35(41)45-23-11-20-38-21-18-36(19-22-38,28-13-6-4-7-14-28)29-15-8-5-9-16-29/h4-10,12-17,24,33,37H,11,18-23H2,1-3H3 checkY
    Key: SVJMLYUFVDMUHP-UHFFFAOYSA-N checkY
  • InChI=1/C36H39N3O6/c1-25-31(34(40)44-3)33(27-12-10-17-30(24-27)39(42)43)32(26(2)37-25)35(41)45-23-11-20-38-21-18-36(19-22-38,28-13-6-4-7-14-28)29-15-8-5-9-16-29/h4-10,12-17,24,33,37H,11,18-23H2,1-3H3
    Key: SVJMLYUFVDMUHP-UHFFFAOYAB
  • (=O)c1cccc(c1)C5C(/C(=O)OC)=C(\N\C(=C5\C(=O)OCCCN4CCC(c2ccccc2)(c3ccccc3)CC4)C)C
Properties
C36H39N3O6
Molar mass 609.71136
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).
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Niguldipine is a calcium channel blocker and α1-adrenergic receptor antagonist.

References

  1. ^ Boer R, Grassegger A, Schudt C, Glossmann H (May 1989). "(+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of alpha 1-adrenoceptors". European Journal of Pharmacology. 172 (2): 131–45. doi:10.1016/0922-4106(89)90004-7. PMID 2548881.
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