In this article, we will thoroughly explore Acetohexamide, a topic that has captured the attention of people from all over the world. Acetohexamide has been the subject of interest and research for years, and its impact can be seen in a wide range of fields, from science and technology to culture and the arts. As we immerse ourselves in the world of Acetohexamide, we will encounter new ideas, exciting discoveries, and fascinating perspectives that are sure to leave us with a deeper understanding and appreciation for this topic. Join us on this fascinating exploration of Acetohexamide and let's discover together everything it has to offer us.
Clinical data | |
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Trade names | Dymelor |
AHFS/Drugs.com | Micromedex Detailed Consumer Information |
MedlinePlus | a602021 |
ATC code | |
Pharmacokinetic data | |
Protein binding | 90% |
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CAS Number | |
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KEGG | |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.012.301 |
Chemical and physical data | |
Formula | C15H20N2O4S |
Molar mass | 324.40 g·mol−1 |
3D model (JSmol) | |
Melting point | 188 to 190 °C (370 to 374 °F) |
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Acetohexamide (trade name Dymelor) is a first-generation sulfonylurea medication used to treat diabetes mellitus type 2, particularly in people whose diabetes cannot be controlled by diet alone.
Acetohexamide bind to an ATP-sensitive K+ (KATP) channel on the cell membrane of pancreatic beta cells. This inhibits the out flux of potassium, which causes the membrane potential to become more positive. This depolarization in turn opens voltage-gated calcium channels. The rise in intracellular calcium leads to increased fusion of insulin granulae with the cell membrane, and therefore increased secretion of insulin.
Oral hypoglycemic drugs, including acetohexamide, have been associated with increased cardiovascular mortality. Qualified healthcare professionals should consulted for possible risks, benefits, and alternatives of using this drug for treatment of type 2 diabetes.