6-Chloronicotine

Today, 6-Chloronicotine is a highly relevant topic that impacts different aspects of our lives. Its influence extends to areas such as technology, health, politics, culture and society in general. Its importance lies in the impact it has on our daily decisions, on the way we relate to our environment and on the way we understand the world around us. Throughout history, 6-Chloronicotine has evolved and generated significant debate, innovation and change. In this article we will explore how 6-Chloronicotine has shaped and influenced our present, and what we can expect from its future.

Chemical compound

6-Chloronicotine

Identifiers
IUPAC name 2-chloro-5-pyridine
CAS Number	112091-17-5
PubChem CID	10631771
ChemSpider	8807133
CompTox Dashboard (EPA)	DTXSID90442718
Chemical and physical data
Formula	C10H13ClN2
Molar mass	196.68 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN1CCC1C2=CN=C(C=C2)Cl
InChI InChI=1S/C10H13ClN2/c1-13-6-2-3-9(13)8-4-5-10(11)12-7-8/h4-5,7,9H,2-3,6H2,1H3/t9-/m0/s1 Key:SVVOLGNZRGLPIU-VIFPVBQESA-N

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6-Chloronicotine is a drug which acts as an agonist at neural nicotinic acetylcholine receptors. It substitutes for nicotine in animal studies with around twice the potency, and shows antinociceptive effects.

See also

• ABT-418
• Altinicline
• Epibatidine
• Tebanicline

References

1. ^ Dukat M, Fiedler W, Dumas D, Damaj I, Martin BR, Rosecrans JA, James JR, Glennon RA (1996). "Pyrrolidine-modified and 6-substituted analogs of nicotine: A structure—affinity investigation". European Journal of Medicinal Chemistry. 31 (11): 875–888. doi:10.1016/S0223-5234(97)89850-9.
2. ^ Damaj MI, Fei-Yin M, Dukat M, Glassco W, Glennon RA, Martin BR (March 1998). "Antinociceptive responses to nicotinic acetylcholine receptor ligands after systemic and intrathecal administration in mice". The Journal of Pharmacology and Experimental Therapeutics. 284 (3): 1058–65. PMID 9495867.
3. ^ Dukat M, Dowd M, Damaj MI, Martin B, El-Zahabi MA, Glennon RA (1999). "Synthesis, receptor binding and QSAR studies on 6-substituted nicotine derivatives as cholinergic ligands". European Journal of Medicinal Chemistry. 34 (1): 31–40. doi:10.1016/S0223-5234(99)80038-5.
4. ^ Latli B, D'Amour K, Casida JE (June 1999). "Novel and potent 6-chloro-3-pyridinyl ligands for the alpha4beta2 neuronal nicotinic acetylcholine receptor". Journal of Medicinal Chemistry. 42 (12): 2227–34. doi:10.1021/jm980721x. PMID 10377228.

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