У Вікіпедыі ёсць артыкулы пра іншых асоб з прозвішчам
Браўн .
Майкл Сцюарт Браўн (англ. : Michael Stuart Brown , нар. 13 красавіка 1941 , Нью-Ёрк , ЗША ) — амерыканскі генетык , лаўрэат Нобелеўскай прэміі па фізіялогіі і медыцыне ў 1985 годзе разам з Дж. Л.Голдстайнам за даследаванні спадчыннай гіперхалестэрэніміі і адкрыццё рэцэптара ліпапратэінаў нізкай шчыльнасці.
Біяграфія
Браўн нарадзіўся ў Брукліне, Нью-Ёрк у сям'і Эвелін Кац і Харві Браўна. Скончыў Пенсільванскі ўніверсітэт у 1962 годзе. З 1968 года ў Нацыянальным інстытуце артрытаў і абменных хвароб, з 1971 года прафесар у Тэхаскім універсітэце, у 1980 годзе дырэктар Цэнтра генетычных хвароб у Паўднёва-Заходняй медыцынскай школе Тэхаскага ўніверсітэта.
Аўтар навуковых прац па механізме транспарту ліпідаў і рэгуляцыі халестэрынавага абмену ў арганізме чалавека і жывёл.
Доктар медыцыны (1966 ).
Член Нацыянальнай акадэміі навук ЗША , Амерыканскай акадэміі навук і мастацтва.
Узнагароды
Лаўрэат шматлікіх прэмій, у тым ліку:
Большасць прэмій атрымаў разам з Джозефам Голдстайнам .
Асноўныя публікацыі
Brown MS, Goldstein JL (1974). "Expression of the familial hypercholesterolemia gene in heterozygotes: mechanism for a dominant disorder in man" . Science . 185 (4145): 61–3. doi :10.1126/science.185.4145.61 . PMID 4366052 .
Brown MS, Goldstein JL (1975). "Regulation of the activity of the low density lipoprotein receptor in human fibroblasts" . Cell . 6 (3): 307–16. doi :10.1016/0092-8674(75)90182-8 . PMID 212203 .
Goldstein JL, Basu SK, Brunschede GY, Brown MS (1976). "Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans" . Cell . 7 (1): 85–95. doi :10.1016/0092-8674(76)90258-0 . PMID 181140 . Папярэджанні CS1: розныя назвы: authors list (link )
Brown MS, Goldstein JL (1976). "Receptor-mediated control of cholesterol metabolism" . Science . 191 (4223): 150–4. doi :10.1126/science.174194 . PMID 174194 .
Goldstein JL, Sobhani MK, Faust JR, Brown MS (1976). "Heterozygous familial hypercholesterolemia: failure of normal allele to compensate for mutant allele at a regulated genetic locus" . Cell . 9 (2): 195–203. doi :10.1016/0092-8674(76)90110-0 . PMID 184960 . Папярэджанні CS1: розныя назвы: authors list (link )
Brown MS, Goldstein JL (1976). "Analysis of a mutant strain of human fibroblasts with a defect in the internalization of receptor-bound low density lipoprotein" . Cell . 9 (4 PT 2): 663–74. doi :10.1016/0092-8674(76)90130-6 . PMID 189940 .
Anderson RG, Brown MS, Goldstein JL (1977). "Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts" . Cell . 10 (3): 351–64. doi :10.1016/0092-8674(77)90022-8 . PMID 191195 . Папярэджанні CS1: розныя назвы: authors list (link )
Goldstein JL, Brown MS, Stone NJ (1977). "Genetics of the LDL receptor: evidence that the mutations affecting binding and internalization are allelic" . Cell . 12 (3): 629–41. doi :10.1016/0092-8674(77)90263-X . PMID 200368 . Папярэджанні CS1: розныя назвы: authors list (link )
Anderson RG, Goldstein JL, Brown MS (1977). "A mutation that impairs the ability of lipoprotein receptors to localise in coated pits on the cell surface of human fibroblasts". Nature . 270 (5639): 695–9. doi :10.1038/270695a0 . PMID 201867 . {{cite journal }}
: Папярэджанні CS1: розныя назвы: authors list (link )
Anderson RG, Vasile E, Mello RJ, Brown MS, Goldstein JL (1978). "Immunocytochemical visualization of coated pits and vesicles in human fibroblasts: relation to low density lipoprotein receptor distribution" . Cell . 15 (3): 919–33. doi :10.1016/0092-8674(78)90276-3 . PMID 215316 . Папярэджанні CS1: розныя назвы: authors list (link )
Goldstein JL, Anderson RG, Brown MS (1979). "Coated pits, coated vesicles, and receptor-mediated endocytosis". Nature . 279 (5715): 679–85. doi :10.1038/279679a0 . PMID 221835 . Папярэджанні CS1: розныя назвы: authors list (link )
Mello RJ, Brown MS, Goldstein JL, Anderson RG (1980). "LDL receptors in coated vesicles isolated from bovine adrenal cortex: binding sites unmasked by detergent treatment" . Cell . 20 (3): 829–37. doi :10.1016/0092-8674(80)90329-3 . PMID 6251975 . Папярэджанні CS1: розныя назвы: authors list (link )
Brown MS, Kovanen PT, Goldstein JL (1981). "Regulation of plasma cholesterol by lipoprotein receptors" . Science . 212 (4495): 628–35. doi :10.1126/science.6261329 . PMID 6261329 . Папярэджанні CS1: розныя назвы: authors list (link )
Basu SK, Goldstein JL, Anderson RG, Brown MS (1981). "Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts" . Cell . 24 (2): 493–502. doi :10.1016/0092-8674(81)90340-8 . PMID 6263497 . Папярэджанні CS1: розныя назвы: authors list (link )
Tolleshaug H, Goldstein JL, Schneider WJ, Brown MS (1982). "Posttranslational processing of the LDL receptor and its genetic disruption in familial hypercholesterolemia" . Cell . 30 (3): 715–24. doi :10.1016/0092-8674(82)90276-8 . PMID 6291781 . Папярэджанні CS1: розныя назвы: authors list (link )
Basu SK, Goldstein JL, Brown MS (1983). "Independent pathways for secretion of cholesterol and apolipoprotein E by macrophages" . Science . 219 (4586): 871–3. doi :10.1126/science.6823554 . PMID 6823554 . Папярэджанні CS1: розныя назвы: authors list (link )
Brown MS, Anderson RG, Goldstein JL (1983). "Recycling receptors: the round-trip itinerary of migrant membrane proteins" . Cell . 32 (3): 663–7. doi :10.1016/0092-8674(83)90052-1 . PMID 6299572 . Папярэджанні CS1: розныя назвы: authors list (link )
Tolleshaug H, Hobgood KK, Brown MS, Goldstein JL (1983). "The LDL receptor locus in familial hypercholesterolemia: multiple mutations disrupt transport and processing of a membrane receptor" . Cell . 32 (3): 941–51. doi :10.1016/0092-8674(83)90079-X . PMID 6299582 . Папярэджанні CS1: розныя назвы: authors list (link )
Larkin JM, Brown MS, Goldstein JL, Anderson RG (1983). "Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts" . Cell . 33 (1): 273–85. doi :10.1016/0092-8674(83)90356-2 . PMID 6147196 . Папярэджанні CS1: розныя назвы: authors list (link )
Orci L, Brown MS, Goldstein JL, Garcia-Segura LM, Anderson RG (1984). "Increase in membrane cholesterol: a possible trigger for degradation of HMG CoA reductase and crystalloid endoplasmic reticulum in UT-1 cells" . Cell . 36 (4): 835–45. doi :10.1016/0092-8674(84)90033-3 . PMID 6705048 . Папярэджанні CS1: розныя назвы: authors list (link )
Chin DJ; Gil G; Russell DW; et al. (1984). "Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum". Nature . 308 (5960): 613–7. doi :10.1038/308613a0 . PMID 6546784 .
Russell DW, Schneider WJ, Yamamoto T, Luskey KL, Brown MS, Goldstein JL (1984). "Domain map of the LDL receptor: sequence homology with the epidermal growth factor precursor" . Cell . 37 (2): 577–85. doi :10.1016/0092-8674(84)90388-X . PMID 6327078 . Папярэджанні CS1: розныя назвы: authors list (link )
Reynolds GA; Basu SK; Osborne TF; et al. (1984). "HMG CoA reductase: a negatively regulated gene with unusual promoter and 5' untranslated regions" . Cell . 38 (1): 275–85. doi :10.1016/0092-8674(84)90549-X . PMID 6088070 . ;
Yamamoto T; Davis CG; Brown MS; et al. (1984). "The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA" . Cell . 39 (1): 27–38. doi :10.1016/0092-8674(84)90188-0 . PMID 6091915 . ;
Lehrman MA, Schneider WJ, Südhof TC, Brown MS, Goldstein JL, Russell DW (1985). "Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains" . Science . 227 (4683): 140–6. doi :10.1126/science.3155573 . PMID 3155573 . Папярэджанні CS1: розныя назвы: authors list (link )
Südhof TC, Goldstein JL, Brown MS, Russell DW (1985). "The LDL receptor gene: a mosaic of exons shared with different proteins" . Science . 228 (4701): 815–22. doi :10.1126/science.2988123 . PMID 2988123 . Папярэджанні CS1: розныя назвы: authors list (link )
Südhof TC, Russell DW, Goldstein JL, Brown MS, Sanchez-Pescador R, Bell GI (1985). "Cassette of eight exons shared by genes for LDL receptor and EGF precursor" . Science . 228 (4701): 893–5. doi :10.1126/science.3873704 . PMID 3873704 . Папярэджанні CS1: розныя назвы: authors list (link )
Gil G, Faust JR, Chin DJ, Goldstein JL, Brown MS (1985). "Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme" . Cell . 41 (1): 249–58. doi :10.1016/0092-8674(85)90078-9 . PMID 3995584 . Папярэджанні CS1: розныя назвы: authors list (link )
Lehrman MA, Goldstein JL, Brown MS, Russell DW, Schneider WJ (1985). "Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain" . Cell . 41 (3): 735–43. doi :10.1016/S0092-8674(85)80054-4 . PMID 3924410 . Папярэджанні CS1: розныя назвы: authors list (link )
Osborne TF, Goldstein JL, Brown MS (1985). "5' end of HMG CoA reductase gene contains sequences responsible for cholesterol-mediated inhibition of transcription" . Cell . 42 (1): 203–12. doi :10.1016/S0092-8674(85)80116-1 . PMID 3860301 . Папярэджанні CS1: розныя назвы: authors list (link )
Brown MS, Goldstein JL (1985). "Scavenger cell receptor shared". Nature . 316 (6030): 680–1. doi :10.1038/316680a0 . PMID 4033768 .
Brown MS, Goldstein JL (1986). "A receptor-mediated pathway for cholesterol homeostasis" . Science . 232 (4746): 34–47. doi :10.1126/science.3513311 . PMID 3513311 .
Davis CG, Lehrman MA, Russell DW, Anderson RG, Brown MS, Goldstein JL (1986). "The J.D. mutation in familial hypercholesterolemia: amino acid substitution in cytoplasmic domain impedes internalization of LDL receptors" . Cell . 45 (1): 15–24. doi :10.1016/0092-8674(86)90533-7 . PMID 3955657 . Папярэджанні CS1: розныя назвы: authors list (link )
Yamamoto T, Bishop RW, Brown MS, Goldstein JL, Russell DW (1986). "Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit" . Science . 232 (4755): 1230–7. doi :10.1126/science.3010466 . PMID 3010466 . Папярэджанні CS1: розныя назвы: authors list (link )
Lehrman MA, Goldstein JL, Russell DW, Brown MS (1987). "Duplication of seven exons in LDL receptor gene caused by Alu-Alu recombination in a subject with familial hypercholesterolemia" . Cell . 48 (5): 827–35. doi :10.1016/0092-8674(87)90079-1 . PMID 3815525 . Папярэджанні CS1: розныя назвы: authors list (link )
Südhof TC, Russell DW, Brown MS, Goldstein JL (1987). "42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter" . Cell . 48 (6): 1061–9. doi :10.1016/0092-8674(87)90713-6 . PMID 3030558 . Папярэджанні CS1: розныя назвы: authors list (link )
Davis CG, Goldstein JL, Südhof TC, Anderson RG, Russell DW, Brown MS (1987). "Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region". Nature . 326 (6115): 760–5. doi :10.1038/326760a0 . PMID 3494949 . {{cite journal }}
: Папярэджанні CS1: розныя назвы: authors list (link )
Hofmann SL, Russell DW, Brown MS, Goldstein JL, Hammer RE (1988). "Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice" . Science . 239 (4845): 1277–81. doi :10.1126/science.3344433 . PMID 3344433 . Папярэджанні CS1: розныя назвы: authors list (link )
Reiss Y, Goldstein JL, Seabra MC, Casey PJ, Brown MS (1990). "Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides" . Cell . 62 (1): 81–8. doi :10.1016/0092-8674(90)90242-7 . PMID 2194674 . Папярэджанні CS1: розныя назвы: authors list (link )
Yokode M, Hammer RE, Ishibashi S, Brown MS, Goldstein JL (1990). "Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors" . Science . 250 (4985): 1273–5. doi :10.1126/science.2244210 . PMID 2244210 . Папярэджанні CS1: розныя назвы: authors list (link )
Seabra MC, Reiss Y, Casey PJ, Brown MS, Goldstein JL (1991). "Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit" . Cell . 65 (3): 429–34. doi :10.1016/0092-8674(91)90460-G . PMID 2018975 . Папярэджанні CS1: розныя назвы: authors list (link )
Chen WJ, Andres DA, Goldstein JL, Russell DW, Brown MS (1991). "cDNA cloning and expression of the peptide-binding beta subunit of rat p21ras farnesyltransferase, the counterpart of yeast DPR1/RAM1" . Cell . 66 (2): 327–34. doi :10.1016/0092-8674(91)90622-6 . PMID 1855253 . Папярэджанні CS1: розныя назвы: authors list (link )
Seabra MC, Brown MS, Slaughter CA, Südhof TC, Goldstein JL (1992). "Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product" . Cell . 70 (6): 1049–57. doi :10.1016/0092-8674(92)90253-9 . PMID 1525821 . Папярэджанні CS1: розныя назвы: authors list (link )
Brown MS, Goldstein JL (1992). "Koch's postulates for cholesterol" . Cell . 71 (2): 187–8. doi :10.1016/0092-8674(92)90346-E . PMID 1423585 .
Andres DA; Seabra MC; Brown MS; et al. (1993). "cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein" . Cell . 73 (6): 1091–9. doi :10.1016/0092-8674(93)90639-8 . PMID 8513495 . ;
Yokoyama C; Wang X; Briggs MR; et al. (1993). "SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene". Cell . 75 (1): 187–97. doi :10.1016/S0092-8674(05)80095-9 . PMID 8402897 . ;
Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS (1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle" . Cell . 76 (5): 865–73. doi :10.1016/0092-8674(94)90361-1 . PMID 8124722 . Папярэджанні CS1: розныя назвы: authors list (link )
Wang X, Sato R, Brown MS, Hua X, Goldstein JL (1994). "SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis" . Cell . 77 (1): 53–62. doi :10.1016/0092-8674(94)90234-8 . PMID 8156598 . Папярэджанні CS1: розныя назвы: authors list (link )
Sakai J, Duncan EA, Rawson RB, Hua X, Brown MS, Goldstein JL (1996). "Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment" . Cell . 85 (7): 1037–46. doi :10.1016/S0092-8674(00)81304-5 . PMID 8674110 . Папярэджанні CS1: розныя назвы: authors list (link )
Hua X, Nohturfft A, Goldstein JL, Brown MS (1996). "Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein" . Cell . 87 (3): 415–26. doi :10.1016/S0092-8674(00)81362-8 . PMID 8898195 . Папярэджанні CS1: розныя назвы: authors list (link )
Brown MS, Goldstein JL (1997). "The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor" . Cell . 89 (3): 331–40. doi :10.1016/S0092-8674(00)80213-5 . PMID 9150132 .
DeBose-Boyd RA, Brown MS, Li WP, Nohturfft A, Goldstein JL, Espenshade PJ (1999). "Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi" . Cell . 99 (7): 703–12. doi :10.1016/S0092-8674(00)81668-2 . PMID 10619424 . Папярэджанні CS1: розныя назвы: authors list (link )
Brown MS, Ye J, Rawson RB, Goldstein JL (2000). "Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans" . Cell . 100 (4): 391–8. doi :10.1016/S0092-8674(00)80675-3 . PMID 10693756 . Папярэджанні CS1: розныя назвы: authors list (link )
Nohturfft A, Yabe D, Goldstein JL, Brown MS, Espenshade PJ (2000). "Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes" . Cell . 102 (3): 315–23. doi :10.1016/S0092-8674(00)00037-4 . PMID 10975522 . Папярэджанні CS1: розныя назвы: authors list (link )
Yang T; Espenshade PJ; Wright ME; et al. (2002). "Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER" . Cell . 110 (4): 489–500. doi :10.1016/S0092-8674(02)00872-3 . PMID 12202038 . ;
Зноскі
Літаратура
Беларуская энцыклапедыя: У 18 т. Т.3: Беларусы — Варанец / Рэдкал.: Г. П. Пашкоў і інш — Мінск: БелЭн, 1996. — Т. 3. — 511 с. — 10 000 экз. — ISBN 985-11-0068-4
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